Creation: Free Design

January 2014

In Science: Potato blight lineage adapted to new host proteases.

A collaboration with the laboratory of Sophien Kamoun (Sainsbury lab, Norwich, UK) resulted in the discovery of the molecular details of host adaptation of a Phytophthora infestans lineage that jumped onto a different host species about 1300 years ago. The protease content of this new host species is different, which forced the pathogen to adapt its protease inhibitors. A single amino acid residue exchange underpins host adaptation and is associated with a reduced ability to manipulate the proteases from the former host. Published in Science. Comments published in Science, The Scientist, and Oxford Media.